Product Safety Information for Dapoxetine (Priligy)
Dapoxetine – Important Safety Information
What Priligy is and what it is used for
Priligy contains an active substance called ‘dapoxetine’. This belongs to a group of medicines called ‘selective serotonin reuptake inhibitors’ (SSRIs). Priligy may also be known as a ‘urological’ medicine.
Priligy increases the time it takes to ejaculate and can improve the control over the ejaculation. This may reduce the frustration or worry about fast ejaculation.
Priligy is used to treat premature ejaculation in adult men aged 18 to 64 years.
Premature ejaculation is when a man ejaculates with little sexual stimulation and before the man wants. This can cause problems for the man and may cause problems in sexual relationships.
What you need to know before you take Priligy
Do not take Priligy if:
you are allergic to dapoxetine or any of the other ingredients of this medicine (listed below)
you have heart problems, such as heart failure or problems with the heart rhythm
you have a history of fainting
you have ever had mania (symptoms include feeling over−excited, irritable or not being able to think clearly) or severe depression
you have moderate or severe liver problems.
you are taking:
Medicines for depression called ‘monoamine oxidase inhibitors’ (MAOIs)
Thioridazine used for schizophrenia
Other medicines for depression
Lithium − a medicine for bipolar disorder
Linezolid − an antibiotic used to treat infections
Tryptophan − a medicine to help you sleep
St John’s wort − a herbal medicine
Tramadol − used to treat serious pain
Medicines used to treat migraines.
Do not take Priligy at the same time as any of the medicines listed above. If you have taken any of these medicines, you will need to wait 14 days after you stop taking it before you can start taking Priligy. Once you have stopped taking Priligy, you will need to wait 7 days before taking any of the medicines listed above. If you are not sure about what to do, talk to your doctor or pharmacist before taking this medicine.
Certain medicines for fungal infection, including ketoconazole and itraconazole
Certain medicines for HIV, including ritonavir, saquinavir, nelfinavir and atazanavir
Certain antibiotics for treating infection, including telithromycin
Nefazodone − an antidepressant
Tell your doctor or pharmacist if you are taking any of the following medicines:
Medicines for mental health problems other than depression
Non−steroidal anti−inflammatory medicines such as ibuprofen or acetylsalicylic acid
Medicines to thin your blood, such as warfarin
Certain medicines used to treat erectile dysfunction, such as sildenafil, tadalafil or vardenafil, as these medicines may lower your blood pressure, possibly upon standing
Certain medicines used to treat high blood pressure and chest pain (angina) (such as verapamil and diltiazem), or enlarged prostate, as these medicines may also lower your blood pressure, possibly upon standing
Certain other medicines for fungal infection, such as fluconazole
Certain other medicines for HIV, such as amprenavir and fosamprenavir
Certain other antibiotics for treating infection, such as erythromycin and clarithromycin
Aprepitant − used to treat nausea.
If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking this medicine. This is because Priligy can affect the way some other medicines work. Also some other medicines can affect the way Priligy works. Therefore, use of other medicines may affect the maximum dose of Priligy you’re allowed to take.
Talk to your doctor, pharmacist or nurse before taking Priligy if:
You have not been diagnosed with premature ejaculation
You also have another sexual problem, such as erectile dysfunction
You have a history of dizziness from low blood pressure • You use recreational drugs such as ecstasy, LSD, narcotics or benzodiazepines
You drink alcohol (see section “Priligy with food, drink and alcohol”)
You have ever had a mental health problem such as depression, mania (symptoms include feeling over−excited, irritable or not being able to think clearly), bipolar disorder (symptoms include serious mood swings between mania and depression) or schizophrenia (a psychiatric disease)
You have epilepsy
You have a history of bleeding or blood clotting problems
You have kidney problems
You have, or are at risk of, high pressure in the eye (glaucoma).
If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking this medicine.
Before you start taking this medicine, your doctor should perform a test to make sure that your blood pressure doesn’t drop too much when you stand up from lying down.
Children and adolescents
This medicine should not be used in children or adolescents under age 18 years.
Priligy with food, drink and alcohol
Do not drink grapefruit juice within 24 hours prior to taking this medicine as this can increase the level of this medicine in your body.
This medicine can be taken with or without food.
You should take this medicine with at least one full glass of water.
Avoid alcohol when taking this medicine.
The effects of alcohol such as feeling dizzy, sleepy and having slow reactions, may be increased if taken with this medicine.
Drinking alcohol while taking this medicine may increase your risk of injury from fainting or from other side effects.
Pregnancy, breast−feeding and fertility
This medicine should not be taken by women.
Driving and using machines
You may feel sleepy, dizzy, faint, have difficulty concentrating and blurred vision while taking this medicine. If you experience any of these or similar effects, you should avoid driving or operating hazardous machinery. The effects of alcohol may be increased if taken with this medicine and you may be more at risk of injury from fainting or from other side effects if you take this medicine with alcohol.
Priligy contains lactose
This medicine contains lactose (a type of sugar). If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Priligy contains sodium
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodium free’.
How to take Priligy
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
The recommended dose is 30 mg. Your doctor may increase the dose to 60 mg.
Only take the medicine 1 to 3 hours before sexual activity is anticipated.
Do not take this medicine more than once every 24 hours or every day.
Swallow the tablets whole to avoid a bitter taste, with at least one full glass of water. This may help lower your chance of fainting (see ‘Fainting and low blood pressure’ below)
This medicine can be taken with or without food.
This medicine should not be used by men under 18 or over 65 years of age.
Discuss your Priligy treatment with your doctor after the first 4 weeks or after 6 doses to see whether you should continue treatment. If treatment is continued, you should see your doctor again to discuss this at least every six months.
If you take more Priligy than you should
Tell your doctor or pharmacist if you have taken more tablets than you should. You may feel sick or be sick.
If you stop taking Priligy
Talk to your doctor before you stop taking this medicine. You may have problems sleeping and feel dizzy after you stop taking this medicine, even if you have not taken it every day.
If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Stop taking Priligy and see your doctor straight away if:
You have fits (seizures)
You faint or feel light headed when you stand up
You notice any changes in your mood
You have any thoughts of suicide or harming yourself.
If you notice any of the above, stop taking this medicine and see your doctor straight away.
Fainting and low blood pressure
This medicine can make you faint or make your blood pressure drop when you stand up. To help lower the chance of this happening:
Take this medicine with at least one full glass of water.
Do not take this medicine if you are dehydrated (you do not have enough water in your body).
This can happen if:
- You have not had anything to drink in the past 4 to 6 hours
- You have been sweating for a long time
- You have an illness where you have a high temperature, diarrhea or being sick.
If you feel like you might faint (such as feeling sick, feeling dizzy, light headed, confused, sweaty or an abnormal heart beat), or feel light headed when you stand up, immediately lie down so your head is lower than the rest of your body or sit down with your head between your knees until you feel better. This will stop you from falling and hurting yourself if you do faint.
Do not stand up quickly after you have been sitting or lying down for a long time.
Do not drive or use any tools or machines if you feel faint when taking this medicine.
Tell your doctor if you faint when taking this medicine.
Very common side effects (may affect more than 1 in 10 men):
Common side effects (may affect up to 1 in 10 men):
Feeling irritable, anxious, agitated or restless
Feeling numb or having ‘pins and needles’
Difficulty getting or keeping an erection
Sweating more than normal or flushing
Diarrhea, constipation or having wind
Stomach pain, bloating or being sick
Problems sleeping or strange dreams
Feeling tired or sleepy, yawning
Blocked nose (nasal congestion)
A rise in blood pressure
Shaking or trembling
Lower interest in sex
Ringing in the ears
Uncommon side effects (may affect up to 1 in 100 men):
Fainting or feeling dizzy upon standing (see advice above)
Change in mood, feeling overly excited or feelings of paranoia
Feeling confused, disoriented or unable to think clearly
Slow or irregular heartbeat or increase in heart rate
Loss of sex drive, problems reaching orgasm
Feeling weak, sedated, lethargic or fatigued
Feeling depressed, nervous or indifferent
Feeling hot, jittery, abnormal or drunk
Vision problems, eye pain or dilated pupils
Low or high blood pressure
Feeling itchy or cold sweat
Rare side effects (may affect up to 1 in 1,000 men):
Feeling dizzy following exertion
Sudden onset of sleep
Urgency of bowel action.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.
What Priligy contains
The active substance is dapoxetine. Each tablet contains 30 mg or 60 mg dapoxetine as a hydrochloride salt.
The other ingredients are:
Tablet core: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate.
Tablet coating: lactose monohydrate, hypromellose, titanium dioxide (E171), triacetin, Iron Oxide Black (E172), Iron Oxide Yellow (E172).